Collectively, These Data Demonstrate That, in the Presence of PTEN, Palbociclib Suppresses GBM Cell Proliferation Through Downregulation of Phospho-ERK and Phospho-Akt Levels, Indicating PTEN Contributes to the Selectivity of Palbociclib Against GBM Through Blocking ERK and Akt Signaling. The gene discussed is AKT1; the disease is glioblastoma.