Despite, mitochondria appearing to be involved in perpetuating the effect of hyperglycemia by producing ROS, the impairment of mitochondrial oxidative metabolism may also play a pivotal role in the pathogenesis of PD as demonstrated by the downregulation of genes responsive to peroxisome PGC-1α (Zheng et al., 2010) which, in turn, is the master regulator of mitochondrial biogenesis and function (Sergi et al., 2019). This evidence concerns the gene PPARGC1A and Hyperglycemia.