LRRK2 and Parkinson disease: For example, p.G2385R in the LRRK2 gene is common among Chinese and Japanese populations and approximately doubles the risk for PD (Bonifati, 2007), while the REP1 microsatellite marker of the SNCA promoter region was consistently associated with a 1.4-fold increased risk of PD (for a review, see Warner and Schapira, 2003; Polito et al., 2016).