While the causal role of Tau in the disease is supported by several inherited tauopathies triggered by dominant missense mutations in the protein, such as TauP301L, causing fronto-temporal dementia with parkinsonism on chromosome 17 (FTDP-17) (Hutton et al., 1998), the etiology of these disorders and the contribution of microglia to their physiopathology remain poorly understood (Hansen et al., 2018; Laurent et al., 2018; Perea et al., 2018). This evidence concerns the gene MAPT and tauopathy.