To investigate the behavior of microglial cells in a tauopathy disease context in vivo, we used the transgenic Tg(HuC-hTauP301L:DsRed) zebrafish model of Tau-induced neurodegeneration, combined with the transgenic Tg(ApoE-eGFP) microglia marker line. The gene discussed is MAPT; the disease is tauopathy.