In mice with increased intraocular pressure, used as models of glaucoma or ischemia-reperfusion, AT1R blockade reduced oxidative stress, inhibited the increase of extracellular glutamate, and mitigated ganglion cell loss (Yang et al., 2009; Fujita et al., 2012; Liu et al., 2012; Quigley et al., 2015). This evidence concerns the gene AGTR1 and glaucoma.