Serum levels of factor B (FB) were decreased and serum levels of mannose-binding lectin (MBL) were elevated in patients with glial tumor, suggesting that low levels of MBL might protect against the initiation and progression of glioblastoma multiforme [112]; furthermore, high serum levels of mannan-binding lectin-associated serine protease 2 (MASP-2) predicted recurrence and poor survival in colorectal cancer patients [113]. The gene discussed is MBL2; the disease is glioma.