In the light of clinical success of bevacizumab (Avastin®), a humanized mAb against vascular endothelial growth factor (VEGF), the anti-angiogenic treatment approaches of solid tumors have been extensively investigated, including a recent report by Nishimura and colleagues on tumor neovasculature-targeted PIT using IR700-conjugated anti-VEGF receptor 2 mAb [11]. Here, VEGFA is linked to neoplasm.