The probable mechanism might be pancreatic lipase inhibition, activation of AMP-Kinase in C2, C12 cells, and hunger sensorymechanism inhibition as per previous scientific reports [14,15] and [18, 19].This study demonstrates the anti hyper lipidemic and anti-obesity potential of Myristica fragrans extract and offers scientific validation and basis to develop anti-obesity drugs. This evidence concerns the gene PNLIP and obesity disorder.