A tissue microarray containing 103 non-small-cell lung carcinoma (NSCLC) resections revealed that NEDD4-1 is negatively correlated with PTEN protein, and the proliferation of NSCLC cells in vitro and in vivo was significantly inhibited due to the suppression of NEDD4-1 expression52. The gene discussed is NEDD4; the disease is non-small cell lung carcinoma.