In the close examination, 3 genes (Itgb6, Cacna2d3, and Cacna1c) were downregulated in 2-week-old cKO hearts, compared to 15 genes downregulated in KEGG_dilated cardiomyopathy pathway in 6-week-old cKO. The gene discussed is ITGB6; the disease is dilated cardiomyopathy.