Increased levels of IL‐6, IL‐10, TNF‐α, and sTNFR in HCV‐infected patients with complications such as cryoglobulinemia, Sjogren syndrome, lymphoproliferative diseases, hemophilia, and HCV related arthritis have been reported compared to CHC‐infected patients without such complications or to healthy controls.45, 51, 56, 164, 165, 166, 167, 168, 169, 170. The gene discussed is IL6; the disease is cryohydrocytosis.