In addition, we determined the mean CD20+ area fraction in patients classified as B cell rich and those classified as B cell poor according to the semiquantitative scores and demonstrated a significantly higher CD20+ area fraction in B cell–rich patients, as shown in Figures 2E and F (mean ± SD area fraction 1.4 ± 1.6 in B cell–rich patients and 0.02 ± 0.05 in B cell–poor patients in the early RA cohort [P < 0.0001] and 1.3 ± 1.9 in B cell–rich patients and 0.04 ± 0.1 in B cell–poor patients in the TNFi‐IR cohort [P < 0.0001]). This evidence concerns the gene MS4A1 and rheumatoid arthritis.