Conversely, in the cohort of patients with established disease (TNFi‐IR), while the significant association of B cell–rich synovitis with histologic synovitis and immune cell infiltration was maintained (Table 2 and Figure 4B), the only significant difference in terms of systemic inflammation or disease activity was a higher CRP level in B cell–rich patients than in B cell–poor patients (Table 2 and Figure 4C) (P = 0.001). This evidence concerns the gene CRP and synovitis.