The HCC tissues with strong M2 macrophage marker CD163 staining showed higher expression of LINC00662 and WNT3A than that with weak CD163 staining (Fig. 7E,F and Fig. S4), which supporting the regulatory axis of LINC00662, WNT3A, and M2 macrophage polarization. Here, WNT3A is linked to hepatocellular carcinoma.