Long non‐coding RNAs (lncRNAs) is a class of transcripts without coding capacity at a length of >200 nt and has reported to play critical roles in the pathogenesis and drug resistance of ESCC.10, 11 LncRNA CCAT2 is associated with poor prognosis of ESCC.12 High expression of lncRNA TUG1 is identified to be associated with chemotherapy resistance and poor prognosis of patients with ESCC.13 Kang et al14 have revealed that lncRNA PART1 acts as a ceRNA to induce gefitinib resistance in ESCC via miR‐129/Bcl‐2 pathway. Here, CCAT2 is linked to esophageal squamous cell carcinoma.