The expression of TLR3 and TLR9 is closely related to the clearance of HPV virus, which is highly expressed in cervical cancer patients.16, 17 In this study, the high expression of TLR3 and TLR9 in HaCaT cell model suggests that TLR3 and TLR9 play an important role in the immune response to HPV infection, and the mechanism may be through TLR signaling pathway. The gene discussed is TLR9; the disease is cervical carcinoma.