In addition, mucosal IgA is locally produced as dIgA in organized gut‐associated lymphoid tissues with site‐specific homing of IgA2 plasmablasts.22 dIgA undergoes transcytosis through epithelial cells via polymeric immunoglobulin receptor into the mucosal lumen.21 Throughout this process polymeric immunoglobulin receptor is cleaved, resulting in a complex consisting of dIgA and secretory component which is released as sIgA (Figure 1).21 Interestingly, the heterogenous forms of IgA have various roles in homeostasis and in infection. This evidence concerns the gene MPIG6B and infection.