We identified a biomarker panel of Hp, LAMP1, SYNE2, and ANXA6 for identification of high‐risk adenomas and two biomarker panels – Hp and LRG1, as well as Hp, LRG1, RBP4, and FN1 – for identification of high‐risk adenomas and CRCs that outperformed hemoglobin. Here, HP is linked to adenoma.