LCT and tuberculosis: Out of several treatments tested (organic solvent delipidation, Proteinase-K, non-specific esterase, phospholipase, phosphatase, urease, creatinase, α-mannosidase, caseinase, and/or lactase treatments), our results showed that α-mannosidase treatment of LAM-spiked urine (for human TB) and combined lactase/caseinase treatment of LAM-spiked milk (for bovine TB) enhanced 10-fold the detection levels of the LAM-test in laboratory settings.