PRKD1 and neuroblastoma: In fact, in SH-SY5Y human neuroblastoma cells, carbachol-dependent HSP-27 phosphorylation on Ser82 and Ser78 residues are prevented by PKC and p38MAPK inhibition, and phorbol esters-dependent HSP-27(Ser82) phosphorylation is reversed by PKC or PKD inhibitors36.