ERBB2 and metastatic malignant neoplasm in the lymph nodes: The reason why high CIN is associated with poor prognosis in HER2-postive subtype is not clear, but in the present study, high CIN status was found to be correlated with lymph node metastasis and lymphovascular invasion in this subtype (p = 0.005, p = 0.011, respectively; data not shown).