To compare the effect of single versus and multiple (3 repeats) treatments, we administered either one injection of 1 × 105 of Pir-PLGA NP-loaded AdSCs or multiple (3) injections of 1/3 the number (3.3 × 104) of Pir-PLGA NP-loaded AdSCs into the marginal site of the tumor on days 21, 28, and 35 after the xenograft transplantation. This evidence concerns the gene PIR and neoplasm.