These mice did not reveal any genotype-specific differences in viremia or serum concentration of IFN-α 1.5 days after infection (Figures S3A–S3C), suggesting that any potential differences seen in expression profiling of liver tissue from Ifnar1Δ/Δ versus Ifnar1+/+ mice is unlikely to be due to altered viral loads and/or systemic IFN-I responses. This evidence concerns the gene IFNAR1 and infection.