BCL2 and premature menopause: It has been reported that in the cisplatin-induced POF model, human umbilical cord mesenchymal stem cell (huMSC)-derived exosomes can significantly up-regulate the expression of the anti-apoptotic protein Bcl-2 and down-regulate the expression of the pro-apoptotic protein c-caspase-3, which indicates that huMSC-exosomes have a protective effect on cisplatin-induced apoptosis of ovarian granulosa cells [23].