IL1B and neoplasm: Il-1B increases 118 +/− 36 fold in human bone isolated from mice injected with MDA-Td Tomato cells that did not metastasise and 371+/− 88 fold in bone isolated from mice injected with MDA-Td Tomato cells that did metastasise compared with bone isolated from mice that were not injected with tumour cells (Fig. 7a).