Recently, two types of CD19-targeted CAR-T cells, tisagenlecleucel (Kymriah), and axicabtagene ciloleucel (Yescarta) were approved by the FDA for the treatment of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) and certain types of large B cell lymphoma [1, 2]. Here, CD19 is linked to acute lymphoblastic leukemia.