Proteins encoded by AD risk genes, including Bridging Integrator 1 (BIN1) [6], CD2AP, EPHA1 [10, 11], PICALM [8], Sortilin Related Receptor 1 (SORL1) [14], amongst others [7, 208, 209] may all interfere with EE function. This evidence concerns the gene SORL1 and Alzheimer disease.