Mutations resulting in repeat expansion are also associated with protein aggregation such as the ALS/FTD linked gene C9ORF72 [92–94], or polyglutamine (polyQ) expansions seen in several disorders, most prominently Huntingtin (HTT) in Huntington’s Disease (HD) [39, 95]. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.