Different from Alisina et al.’s study, we excluded patients with systemic inflammation such as rheumatoid arthritis, psoriasis, SLE, polymyalgia rheumatica, hepatitis B and C, IBD, sarcoidosis, gout, myelodysplastic syndrome, lymphocytic leukemia, and multiple myeloma, as these conditions may induce high expression of CRP, ESR, and D-Dimer [22], which could result in high false positive rates. This evidence concerns the gene CRP and gout.