As both CRP and ESR have their limitations in PJI diagnosis and the Consensus document for the diagnosis of PJI [19] stated serum CRP and ESR should always be performed in patients with suspected PJI, but low CRP and ESR cannot rule out PJI, the meaning of various new serological markers has also been checked in PJI diagnosis [5–13]. The gene discussed is CRP; the disease is juvenile polyposis syndrome.