Recently, gene expression profiling was used to identify diagnostic and predictive biomarkers for high grade PCa followed by a stepwise biomarker selection and testing of a gene panel consisting of Homeobox C6 (HOXC6), Tudor domain containing 1 (TDRD1) and Distal-less homeobox 1 (DLX1) in post-DRE urine sediments for the diagnosis of biopsy Gleason score ≥ 7 PCa [8]. The gene discussed is HOXC6; the disease is posterior cortical atrophy.