We and others have reported that tumor tissue expressed ligands for these chemokine receptors [33–36], and the interactions of CXCL10-CXCR3, CCL1-CCR8, CCL28-CCR10, and CXCL16-CXCR6 could play an important role in recruiting CD8+ T cells into the tumor tissue. The gene discussed is CD8A; the disease is neoplasm.