In addition, the proportion of PD1Hi CD8+ T cells within CD8+PD1+ T cells (median = 54.23, 39.99–71.33%) was significantly higher in tumor than that of peri-tumor (median = 43.08, 30.33–57.76%; P < 0.0001) (Fig. 4e), while the proportions of PD1Int CD8+ T cells were opposite (Tumor, median = 45.65, 28.33–60.00%; peri-tumor, median = 56.57, 41.85–69.14%; P < 0.0001) (Fig. 4f). The gene discussed is PDCD1; the disease is neoplasm.