PD1+ cells among CD8+ T cells in peripheral blood (median = 21.70, 15.49–34.27% [IQR, same for the following]) was greatly increased in peri-tumor tissues (median = 70.82, 54.63–78.01%; P <  0.0001) and further elevated in tumor tissues (median = 76.98, 67.51–88.11%; P <  0.0001) (Fig. 1b). This evidence concerns the gene PDCD1 and neoplasm.