Recently, a prospective genotyping study in 81 patients with advanced HCC treated with sorafenib showed that mechanistic target of rapamycin (mTOR) signaling pathway alterations were associated with a poorer DCR (8.3% versus 40.2% in patients without such alterations) and OS (10.4 versus 17.9 months, respectively) [41]. This evidence concerns the gene MTOR and hepatocellular carcinoma.