In 2015, a first molecular classification divided HCC into two main classes, each representing about 50% of patients, including [38]: (i) the proliferative class, enriched in activation of the RAS pathway, mechanistic target of rapamycin and IGF signaling pathways, FGF19 amplification, associated with HBV infection and with a poor prognosis; (ii) the non-proliferative class, more heterogeneous but characterized by CTNNB1 mutations and associated with alcohol and HCV infection. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.