Other studies are currently evaluating nivolumab in combination with chemoembolization (NCT03572582), radioembolization (NCT03033446), TGF-β inhibitors (NCT02423343), indoleamine dioxygenase inhibitors (NCT03695250) in patients with advanced HCC, or in neo-adjuvant and adjuvant settings (NCT03630640, NCT03383458). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.