In our study, sPD-L2 but not sPD-L1 was predictive of recurrence risk in ccRCC, and sPD-L2 level seems to be higher than that of sPD-L1, which is consistent with the protein expression of these two markers in TILs from another study [4]. This evidence concerns the gene SPDL1 and nonpapillary renal cell carcinoma.