Giraldo et al. reported that in a group of 40 localized ccRCC cases the presence of CD8+PD-1+TIM3+LAG3+ tumor infiltrative lymphocytes (TILs) with CD4+ICOS+ T-reg cells identified patients with deleterious prognosis [3]. The gene discussed is HAVCR2; the disease is nonpapillary renal cell carcinoma.