The RASopathy VCEP published recommendations for PS3/BS3 application in interpretation of variants in nine genes linked to RASopathy conditions: BRAF, HRAS, KRAS, MAP 2K1, MAP 2K2, PTPN11, RAF1, SHOC2, and SOS1 (Table 1; see also Additional file 1 for a detailed discussion of the biological context of assays) [9]. This evidence concerns the gene SOS1 and RASopathy.