The HL VCEP calculated the positive and negative predictive value of functional assays commonly used to assess variants in three genes (COCH, GJB2, SLC26A4) by comparing published assay results with ClinVar classifications [5], while the CDH1 VCEP compared published assay results with data from affected individuals (see the “CDH1 VCEP” and “Hearing Loss VCEP” sections) [4]. The gene discussed is GJB2; the disease is hearing loss disorder.