The Hearing Loss (HL) VCEP developed disease-specific recommendations for variant interpretation in the context of nine genes commonly associated with hearing loss: CDH23, COCH, GJB2, KCNQ4, MYO6, MYO7A, SLC26A4, TECTA, and USH2A (Table 1; see also Additional file 1) [5]. The gene discussed is CDH23; the disease is hearing loss disorder.