Recent pooled analyses of laboratory-based trials indicate that higher energy expenditures of different types of activity breaks (standing, light- or moderate-intensity walking) were associated with lower postprandial glucose and insulin responses in a dose-response manner in overweight/obese sedentary adults [84], and that those with higher underlying levels of insulin resistance may derive greater metabolic benefits from regularly interrupting prolonged sitting with activity breaks than their healthier counterparts [85]. Here, INS is linked to Insulin resistance.