We posit that upon treatment with garcinol, miR-181d canonically represses the activation/phosphorylation of STAT3/5A in a JAK2-mediated manner, or as also documented herein, miR-181d non-canonically binds directly to the coding region of STAT3 or STAT5A mRNA, eliciting STAT3/5A degradation, and consequently impair activation of STAT3 or STAT5A in the GBM cells. The gene discussed is JAK2; the disease is glioblastoma.