Building on previous works by our team demonstrating that garcinol inhibits CSCs-like phenotype by suppressing the Wnt/β-catenin/STAT3 signaling axis in human non-small cell lung carcinoma [30], we now examined the probable effect of garcinol on GBM stem cells (GBM-SCs), and the implication of same for sensitivity to conventional chemotherapy and better prognosis. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.