This present study, for the first time, to the best of our knowledge, investigated and documents the effect of garcinol on GBM, consistent with current theme-relevant knowledge, especially in the context of the therapeutic effects of garcinol alone or in synergism with conventional anticancer treatment modalities on GBM-SCs through the mediation of STAT3/5A signaling and miRNA-181d. The gene discussed is STAT3; the disease is glioblastoma.