Interestingly, low dose garcinol (≤5 μM) deregulated STAT3/5A signaling with repressed AKT and ERK crosstalk, and this was sufficient to significantly impeded GBM cell migration, invasion, clonogenicity, and tumorsphere formation, with associated increase in apoptotic index and nuclear expression of SOX2 and OCT4. This evidence concerns the gene SOX2 and glioblastoma.