These findings indicate that garcinol inhibits tumorigenicity and growth of GBM by abrogating STAT3/5A signaling, and upregulating hsa-miR-181d, with concomitant suppression of Ki-67 proliferation index and enhancement of Bax/Bcl-xL apoptotic ratio, in vivo. The gene discussed is MKI67; the disease is glioblastoma.