STAT3 and neoplasm: Moreover, for tumors extracted from the 1 mg/kg garcinol-treated U87MG tumor-bearing mice, compared to the untreated control group, STAT3, or STAT5A mRNA expression were suppressed by four-fold (p < 0.01) or 3.87-fold (p < 0.01), while miR-181d expression was enhanced by 3.52-fold (p < 0.01) in the U87MG mice treated with 1 mg/kg garcinol (Figure 5E).