Taken together, as depicted in our graphical abstract in Figure 7, the present study provides evidence that the constitutive activation of STAT3/5A in GBM is inversely correlated with suppressed hsa-miR-181d expression, and that JAK2-mediated garcinol-induced upregulation of hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratios underlies the anti-GBM-SCs effect of garcinol in STAT3/5A-addicted GBM. This evidence concerns the gene STAT3 and glioblastoma.