There is also accruing evidence that the prognostic implications of altered miRNA expression, is connected to their roles in modulation of stemness signaling such as Notch, Hedgehog, and JAK/STAT3 [23,28], and the consequent acquisition of stem cell-like traits by GBM cells; thus, the present study’s rationale for exploring the actionability of miRNA-181d in the context of STAT signaling in GBM. The gene discussed is STAT3; the disease is glioblastoma.