Considering these differences in predominance of PCOS phenotypes, it is interesting to speculate whether gestational T exposure plays a crucial developmental role in programming classic PCOS phenotypes with impaired hypothalamic GnRH regulation and dysfunctional ovarian follicle development, as well as adipogenic constraint leading to lipotoxicity and insulin resistance (see below). Here, GNRH1 is linked to polycystic ovary syndrome.