PLOD1 and polycystic ovary syndrome: When considering hypothalamic regulation of female reproduction, early-to-mid gestation T exposure induces the most comprehensive and compelling mimic of PCOS reproductive neuroendocrine dysfunction with increased episodic release of LH [34], and likely hypothalamic GnRH, increased pituitary LH responsiveness to exogenous GnRH [144], chronically elevated basal LH during both follicular and luteal phases of the menstrual cycle [112] as well as during anovulatory periods, with underlying failures of E2- and P4-mediated LH negative feedback [34].