In this regard, positive associations between uterine endometrial thickness in naturally hyperandrogenic females and circulating insulin, HOMA-IR and waist-to-hip ratio [13], may further implicate synergistic hyperandrogenic and metabolic contributions to pregnancy disruption that are manifest in peripubertal T-onset macaque models [132], and could resemble pregnancy complications in women with PCOS [67,101,102]. Here, INS is linked to polycystic ovary syndrome.