A study published earlier this year by Seeger and colleagues made use of genome-editing techniques to create isogenic iPSC lines from patients with heterozygous mutations in the myosin-binding protein C3 (MYBPC3), which is deemed as the underlying cause of hypertrophic cardiomyopathy (HCM) [208]. The gene discussed is MYBPC3; the disease is hypertrophic cardiomyopathy.