In conclusion, our preset study identified the promoter region of the PDSS2 gene for the first time and demonstrated that Sp1 transcription factor could directly regulate the transcription of PDSS2, which not only lays a solid foundation for further elucidation of the PDSS2 regulation mechanism and molecular behavior, but also contributes to further analysis of the biological function of PDSS2 in the development of cancer. Here, SP1 is linked to cancer.