The preventive roles of TNFAIP3 have been widely reported in a number of systemic inflammatory diseases, such as rheumatoid arthritis, autoimmune diseases, gastrointestinal and hepatic disorders, psoriasis, aging, and cancer [36], and also in different viral infections such as measles virus [37], influenza virus [38], and parasitic infection like Leishmania donovani [38]. This evidence concerns the gene TNFAIP3 and viral infectious disease.