We found that hBMECs could downregulate miR-19b-3p expression, which led to attenuated generation of proinflammatory cytokines and chemokines in response to meningitic E. coli infection by upregulating the expression of TNFAIP3, a direct target of miR-19b-3p that exerts the negative regulation of the neuroinflammatory responses. Here, TNFAIP3 is linked to escherichia coli infection.