While no therapy can be entirely selective, use of EGFR-targeted PIC in OvCa has some significant advantages—(i) EGFR is often overexpressed in OvCa leading to highly selective PS delivery in cancer cells compared to normal tissues, (ii) greater dependence of cancer cells on EGFR signaling, and (iii) confinement of light to the peritoneal cavity [87]. This evidence concerns the gene EGFR and cancer.