In this context, it is reasonable to hypothesize that the fusion of chr12:125039000-128113999 and chr12:123760000-124919999 leads to enhancers in chr12:125039000-128113999—which, under normal conditions, would not interact with NCOR2—being hijacked by NCOR2. Aberrant expression of NCOR2 has been associated with several cancers [24]; in particular, the complex formed by NCOR1 and NCOR2 in concert with HDAC3 epigenetically suppresses myogenic differentiation in Embryonal rhabdomyosarcoma (ERMS), which is required for tumor growth [25]. Here, HDAC3 is linked to embryonal rhabdomyosarcoma.