Similarly, T2-weighted MRI was used to show the tumor size dependency on the mammalian target of rapamycin (mTOR) inhibitor rapamycin in a mouse genetic model where EC developed after deletion of the tumor suppressor liver kinase 1B (Lkb1), a negative regulator of the AMP-activated protein kinase (AMPK)-mTOR pathway (Table 1) [26]. This evidence concerns the gene MTOR and neoplasm.