FAT1 and neoplasm: Regardless of the aforementioned consistencies between our present findings and several other published works, we do acknowledge our findings contradict those of Lin et al. [17], suggesting FAT1 acts as a tumor suppressor, with lower FAT1 protein expression bearing significant correlation with lymph node metastasis, lymphovascular permeation, tumor recurrence, and shorter disease-free survival (DFS) in patients with HNSC.