FAT1 and neoplasm: Since the focus of the present study is more specifically OSCC, tapering down from our evolving generic understanding of the role of FAT1 in HNSC, using the Peng Head-Neck OSCC cohort (n = 79), we further demonstrated a 2.82-fold increase in FAT1 expression in the OSCC compared to the ‘normal’ non-tumor oral cavity samples (t-test = 12.0, p = 4.57 × 10–18) (Figure 3A).