We cannot fully explain this contradiction, however, we cautiously attribute this to tumor heterogeneity and/or cohort constitution, based on demonstrated association of high expression of FAT1 with high grade cancerous cells and low FAT1 with low grade cancerous cells in previous works [19,30], as observed in the present work with the use of the HSC-3 and SAS cells which are poorly differentiated human squamous carcinoma of the tongue cells with high lymph node metastasis potential [34,35,36], as well as with our use of OSCC cohorts with more high grade, advanced stage or metastatic cases. The gene discussed is FAT1; the disease is squamous cell carcinoma.