As rightly noted by Soussi and Wiman for p53 (TP53) [37], it is not impossible that while the standard criteria for definition of various cancer genes may confine the tumor protein FAT1 to the role of a tumor suppressor, accruing evidence across multiple cancer types with diverse histology, indicate that FAT1 does indeed act as an oncogene. The gene discussed is TP53; the disease is cancer.