FAT1 and cancer: Finally, consistent with Muller’s exposition on the nature and causes of gene mutations, based on the classification of mutations hinged on genophenotypic analyses [39], genomic alterations in FAT1 are akin to the ‘amorph’ or ‘hypomorphic’ mutation which are more characteristic of so-called ‘tumor suppressors’, wherein the tumor suppressor function is totally impaired or a partial reduced, resulting in its acquisition of oncogenicity and ability to drive cancer.