For instance, as early as 2002, CED was explored to enhance the intracerebral and intratumoural uptake of a heavily boronated macromolecule dendrimer conjugated to epidermal growth factor (EGF) for neutron capture therapy in rats bearing a syngeneic epidermal growth factor receptor (EGFR)-positive glioma [73]. Here, EGF is linked to glioma.