Further, depletion of MARVELD3 by siRNAs in the human pancreatic cancer cell line (HPAC) resulted in downregulation of barrier function as shown by decreased electrical resistance and increased permeability to fluorescent dextran tracers, whereas knockdown did not affect the fence function of TJs maintaining apical and basolateral membrane protein restriction [184]. Here, MARVELD3 is linked to pancreatic neoplasm.