An early step in EMT in cancer cells is loss of gene transcription for junctional components, where the high expression of the transcription regulators Snail, Slug, Twist, zinc finger E-box-binding homeobox 1 (ZEB-1), SMAD interacting protein 1 (Sip-1), and lymphoid enhancer-binding factor 1 (LEF-1) reduces Ocln and Cldn synthesis [39,40] (Figure 2). The gene discussed is ZEB1; the disease is cancer.