Further, depletion of MARVELD3 by siRNAs in the human pancreatic cancer cell line (HPAC) resulted in downregulation of barrier function as shown by decreased electrical resistance and increased permeability to fluorescent dextran tracers, whereas knockdown did not affect the fence function of TJs maintaining apical and basolateral membrane protein restriction [184]. The gene discussed is MARVELD3; the disease is familial pancreatic carcinoma.