CD274 and neoplasm: In summary, while an increase in tumor PD-L1 will, in principle, promulgate evasion from immune surveillance by inactivating host T cells and hence is bad for tumor outcome [47,48,49] by favoring tumorigenesis, the potential negative impact of elevated PD-L1 is countered by the clinical efficacy PLB shows in patients expressing high PD-L1 in their tumors.