CD274 and neoplasm: We therefore postulate that induction of tumor surface PD-L1 by stilbenoids is concomitant with the reorganization of the tumor microenvironment and may serve as a Search, Enhance, and Engage (“SEE”) signal to sensitize low PD-L1-expressing “cold, non-responsive” tumors, augmenting their detection by PLB and elimination by host anti-tumor immunity.