Genetic variants of Apolipoprotein e gene (APOE) have also been shown to affect plasma Lp(a) levels [19], with the APOE ε2 variant strongly associated with low Lp(a) concentrations, although this did not appear to modify any association with myocardial infarction or aortic valve stenosis [20]. This evidence concerns the gene APOE and myocardial infarction.