Finally, and besides its effect on heart rhythm and blood flow, adenosine also interacts with the cardiovascular system via blood and, hence, PBMCs: The upregulation of A2AR results in adenosinergic T-cell immunosuppression during hypoxia [43], and conversely, down-regulation of A2AR in PBMC of CAD patients probably promotes inflammation [44]. The gene discussed is ADORA2A; the disease is coronary artery disorder.