RHBDL2 in DU145 carcinoma cells indued similar effects, which express higher basal levels of E-cadherin (Figure 2B,C, and Figure S3B); thus, we could also detect a striking increase in the shedding of soluble E-cadherin extracellular domain in the conditioned medium of these cells, in response to RHBDL2 expression (Figure 2B). This evidence concerns the gene RHBDL2 and carcinoma.