Intriguingly, different from cancer cells, RHBDL2 overexpression induced a morphological rearrangement in endothelial cells, which was similar to that observed upon cell-cell adhesion dissociation in low-Ca2+ condition (Figure S5A,B); consistently, in response to RHBDL2, endothelial cell migration was also moderately, but significantly, induced (Figure S5C). Here, RHBDL2 is linked to cancer.