Although a recent study reported that TXNIP (thioredoxin interacting protein) is epigenetically repressed by UHRF1 and has a tumor suppressor role in renal cell carcinoma cells (Jiao et al., 2019), our further validation in RB cells revealed that basal TXNIP expression and biological responses to HDAC inhibitors are inconsistent in Y79 and Weri‐Rb1 cells upon UHRF1 depletion (data not shown), suggesting that the role of TXNIP may be tumor‐specific. The gene discussed is HDAC9; the disease is renal cell carcinoma.