Nevertheless, the biological activity of ZNF281/Zfp281 is not limited to embryonic/fetal life; Zfp281 increases cardiac reprogramming of adult mouse fibroblasts by modulating the expression of inflammatory and cardiac genes (Zhou et al., 2017); in normal and transformed cells, ZNF281/Zfp281 down‐regulation promotes osteogenic (Seo et al., 2013) and neuronal differentiation (Pieraccioli et al., 2018), while its expression drives epithelial–mesenchymal transition (EMT) in colon cancer cells (Hahn et al., 2013). Here, ZNF281 is linked to malignant colon neoplasm.