In univariate Cox proportional hazards analysis, the results showed that elderly (hazard ratio (HR): 1.318, 95% confidence interval (CI): 1.003‐1.731, P = .047), female (HR: 1.349, 95% CI: 1.014‐1.796, P = .04), advanced stages (HR: 1.754, 95% CI: 1.203‐2.558, P = .004), lymphatic metastasis (HR: 1.86, 95% CI: 1.343‐2.576, P = 1.86E‐04), and elevated P4HA1 expression (HR: 1.775, 95% CI: 1.358‐2.321, P = 2.68E‐05) were associated with unfavorable OS. Here, P4HA1 is linked to Lymphatic Metastasis.