The history of high alcohol consumption is a crucial factor for increased the risk of HNSCC.24 In this study, using RNA‐seq data in TCGA‐HNSC, we found that increased P4HA1 expression was significantly correlated with alcohol consumption, suggesting that alcohol might contribute to HNSCC by inducing P4HA1 expression. The gene discussed is P4HA1; the disease is head and neck squamous cell carcinoma.