By comparing P4HA1 mRNA expression using the RNA‐Seq data of 520 HNSCC tissues and normal tissues in TCGA, we revealed that HNSCC tissues exhibited significantly elevated P4HA1 mRNA expression compared with normal tissues (P = 1.64E‐23; Figure 1A,B), consistent with our findings using GEO data (P = 6.16E‐04; Figure 1C). The gene discussed is P4HA1; the disease is head and neck squamous cell carcinoma.