We found that high P4HA1 expression (OS: HR: 1.728, 95% CI: 1.267‐2.357, P = .001; RFS: HR: 2.025, 95% CI: 1.296‐3.162, P = .002) was independent unfavorable prognostic factor in terms of OS and RFS in HNSCC patients (Figure 5). This evidence concerns the gene P4HA1 and head and neck squamous cell carcinoma.